Mouse Study Hints at Why Obese People Struggle to Exercise

Mouse Research Hints at Why Overweight Individuals Wrestle to Train

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THURSDAY, Dec. 28, 2016 (HealthDay Information) -- Chubby mice could present a touch as to why it is so exhausting to start out -- and follow -- your New 12 months's decision to train extra.

Researchers discovered indicators that the brains of overweight mice could encourage inactivity.

"We all know that bodily exercise is linked to general good well being, however not a lot is thought about why folks or animals with weight problems are much less energetic," mentioned research senior writer Alexxai Kravitz.

Kravitz is an investigator within the diabetes, endocrinology, and weight problems department of the U.S. Nationwide Institute of Diabetes and Digestive and Kidney Illnesses.

"There is a frequent perception that overweight animals do not transfer as a lot as a result of carrying additional physique weight is bodily disabling. However our findings counsel that assumption does not clarify the entire story," Kravitz mentioned.

Kravitz has theorized that the mind chemical dopamine is vital to inactivity in mice.

"Different research have related dopamine signaling defects to weight problems, however most of them have checked out reward processing -- how animals really feel once they eat completely different meals," Kravitz mentioned.

"We checked out one thing easier: Dopamine is crucial for motion, and weight problems is related to a scarcity of motion," he mentioned. His group puzzled if issues with dopamine signaling alone may clarify the inactivity.

For the research, researchers fed regular and high-fat diets to mice. The mice on the high-fat plan placed on weight and slowed down. However they slowed down earlier than including kilos, elevating questions on why issues occurred in that order.

One potential reply: The researchers discovered that the overweight and slow-moving mice had much less of a "receptor" that processes dopamine.

Additional analysis recommended that weight achieve was compounded by their inactivity.

The research outcomes seem within the Dec. 29 situation of the journal Cell Metabolism.

"In lots of instances, willpower is invoked as a solution to modify habits," Kravitz mentioned in a journal information launch. "But when we do not perceive the underlying bodily foundation for that habits, it is tough to say that willpower alone can remedy it."

Studying extra in regards to the physiological the reason why weight problems is related to much less exercise may also assist cut back a few of the stigma that overweight folks face, the researchers mentioned.

Nonetheless, the outcomes of animal research aren't essentially relevant to people. Way more analysis might be wanted earlier than anybody can say there is a direct connection between dopamine and obesity-related exercise ranges.

-- Randy Dotinga

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SOURCE: Cell Metabolism, information launch, Dec. 29, 2016